Trying to leave their troubled lives behind, twin brothers return to their hometown to start again, only to discover that an even greater evil is waiting to welcome them back.
Twenty-eight years after the Rage virus outbreak, a heavily-defended island survives connected to the mainland by a single causeway. When one of the group leaves the island into the dark heart of the mainland, he discovers secrets, wonders, and horrors that have mutated not only the infected but other survivors as well.
When his family is murdered, a deaf-mute named Boy escapes to the jungle and is trained by a mysterious shaman to repress his childish imagination and become an instrument of death.
Reclusive gym manager Lou falls hard for Jackie, an ambitious bodybuilder headed through town to Las Vegas in pursuit of her dream. But their love ignites violence, pulling them deep into the web of Lou’s criminal family.